The oscillation of mitotic kinase governs cell cycle latches in mammalian cells. Dragoi CM, Kaur E, Barr AR, Tyson JJ, Novak B. J Cell Sci. 2024.
2024
CDK4/6 inhibitor-mediated cell overgrowth triggers osmotic and replication stress to promote senescence. Crozier L*, Foy R*, Adib R*, Kar A, Holt JA, Pareri AU, Valverde JM, Rivera R, Weston WA, Wilson R, Regnault C, Whitfield P, Badonyi M, Bennet LG, Vernon EG, Gamble A, Marsh JA, Stable CJ, Saurin A^, Barr AR^, Ly T^. Molecular Cell. 2023. Nov.
A cell cycle centric view of tumour dormancy. Weston WA, Barr AR. Br J Cancer. 2023. Aug 22.
Endothelial sensing of AHR ligands regulates intestinal homeostasis. Wiggins BG, Wang YF, Burke A, Grunberg N, Vlachaki Walker JM, Dore M, Chahrour C, Pennycook BR, Sanchez-Garrido J, Vernia S, Barr AR, Frankel G, Birdsey GM, Randi AM, Schiering C. Nature. 2023. Sep.
A lack of commitment to proliferation. Barr AR. Nature. 2023. Jul.
Genomic hallmarks and therapeutic implications of G0 cell cycle arrest in cancer. Wiecek AJ, Cutty SJ, Kornai D, Parreno-Centeno M, Gourmet LE, Tagliazucchi GM, Jacobson DH, Zhang P, Xiong L, Bond GL, Barr AR, Secrier M. Genome Biol. 2023. May 23.
2023
2022
Patterns of interdivisional time correlations reveal hidden cell cycle factors. Hughes FA, Barr AR*, Thomas P*. Elife. 2022. Nov 15.
Conserved CDK inhibitors show unique structural responses to tyrosine phosphorylation. Swadling JB, Warnecke T, Morris KL, Barr AR. Biophys J. 2022. May 25.
Cells on lockdown: long-term consequences of CDK4/6 inhibition. Barr AR, McClelland SE. EMBO J. 2022. Mar 15;41(6):e110764.
2021
Palbociclib-mediated cell cycle arrest can occur in the absence of the CDK inhibitors p21 and p27. Pennycook BR, Barr AR. Open Biol. 2021. Nov;11(11):210125.
RUNX1 Regulates a Transcription Program That Affects the Dynamics of Cell Cycle Entry of Naive Resting B Cells. Thomsen I, Kunowska N, de Souza R, Moody AM, Crawford G, Wang YF, Khadayate S, Strid J, Karimi MM, Barr AR, Dillon N, Sabbattini P. J Immunol. 2021. Nov 22;207(12):2976-2991.
2020
Restriction Point regulation at the crossroads of quiescence and proliferation. Pennycook BR, Barr AR. FEBS Lett. 2020. Jun 21 doi: 10.1002/1873-3468.13867.
A high-content RNAi screen reveals multiple roles for long noncoding RNAs in cell division. Stojic L, Lun ATL, Mascalchi P, Ernst C, Redmond AM, Mangei J, Barr AR, Bousgouni V, Bakal C, Marioni JC, Odom DT, Gergely F. Nat Commun. 2020 Apr 15;11(1):1851. doi: 10.1038/s41467-020-14978-7.
E2F activity during S-phase determines replication capacity and S-phase length. Pennycook BR, Vesela E, Peripolli S, Singh T, Barr AR, Bertoli C, de Bruin RAM. Nat Commun. 2020 Jul 14;11(1):3503. doi: 10.1038/s41467-020-17146-z.
Cyclin A triggers Mitosis either via the Greatwall kinase pathway or Cyclin B. Hégarat N, Crncec A, Suarez Peredo Rodriguez MF, Echegaray Iturra F, Gu Y, Busby O, Lang PF, Barr AR, Bakal C, Kanemaki MT, Lamond AI, Novak B, Ly T, Hochegger H. EMBO J. 2020 Apr 30:e104419. doi:10.15252/embj.2020104419.
2018
Specificity of RNAi, LNA and CRISPRi as loss-of-function methods in transcriptional analysis. Stojic L, Lun ATL. Mangei J, Mascalchi P, Quarantotti V, Barr AR, Bakal C, Marioni J, Gergely F, Odom DT. Nucleic Acids Res. 2018 Jun 1. doi: 10.1093/nar/gky437.
A comprehensive model for the proliferation-quiescence decision in response to endogenous DNA damage in human cells. Heldt FS, Barr AR, Cooper S, Bakal C, Novak B. Proc Natl Acad Sci U S A. 2018 Mar 6;115(10):2532-2537. doi: 10.1073/pnas.1715345115.
2017
NucliTrack: an integrated nuclei tracking application. Cooper S, Barr AR, Glen R, Bakal C. Bioinformatics. 2017 Oct 15;33(20):3320-3322. doi: 10.1093/bioinformatics/btx404.
Single-Cell Dynamics Determines Response to CDK4/6 Inhibition in Triple-Negative Breast Cancer. Asghar US, Barr AR, Cutts R, Beaney M, Babina I, Sampath D, Giltnane J, Lacap JA, Crocker JA, Youn A, Pearson A, Herrera-Abreu MT, Bakal C, Turner NC. Clin Cancer Res. 2017 Sep 15;23(18):5561-5572. doi: 10.1158/1078-0432.CCR-17-0369.
DNA damage during S-phase mediates the proliferation-quiescence decision in the subsequent G1 via p21 expression. Barr AR, Cooper S, Heldt FS, Butera F, Stoy H, Mansfeld J, Novak B, Bakal C. Nat Commun. 2017 Mar 20;8:14728. doi: 10.1038/ncomms14728.
2016
A Dynamical Framework for the All-or-None G1/S Transition. Barr AR, Heldt FS, Zhang T, Bakal C, Novak B. Cell Syst. 2016 Jan 27;2(1):27-37. doi: 10.1016/j.cels.2016.01.001.
A CEP215-HSET complex links centrosomes with spindle poles and drives centrosome clustering in cancer. Chavali PL, Chandrasekaran G, Barr AR, Tatrai P, Taylor C, Papachristou EK, Woods CG, Chavali S, Gergely F. Nat Commun. 2016 Mar 18;7:11005. doi: 10.1038/ncomms11005.
2015
A sensitised RNAi screen reveals a ch-TOG genetic interaction network required for spindle assembly. Barr AR, Bakal C. Sci Rep. 2015 Jun 3;5:10564. doi: 10.1038/srep10564.
2013
A screen for morphological complexity identifies regulators of switch-like transitions between discrete cell shapes. Yin Z, Sadok A, Sailem H, McCarthy A, Xia X, Li F, Garcia MA, Evans L, Barr AR, Perrimon N, Marshall CJ, Wong ST, Bakal C. Nat Cell Biol. 2013 Jul;15(7):860-71. doi: 10.1038/ncb2764.
2012
Commentary: A direct look at RNAi screens. Barr AR, Bakal C. Mol Syst Biol. 2012 Apr 24;8:580. doi: 10.1038/msb.2012.14.
2011
A primary microcephaly protein complex forms a ring around parental centrioles. Sir JH, Barr AR, Nicholas AK, Carvalho OP, Khurshid M, Seasick A, Reichelt S, D'Santos C, Woods CG, Gergely F. Nat Genet. 2011 Oct 9;43(11):1147-53. doi: 10.1038/ng.971.
2010
CDK5RAP2 functions in centrosome to spindle pole attachment and DNA damage response. Barr AR, Kilmartin JV, Gergely F. J Cell Biol. 2010 Apr 5;189(1):23-39. doi: 10.1083/jcb.200912163.
2009
Book Chapter: Knock-in and knock-out: the use of reverse genetics in somatic cells to dissect mitotic pathways. Barr AR, Zyss D, Gergely F. Methods Mol Biol. 2009;545:1-19. doi: 10.1007/978-1-60327-993-2_1.
2008
MCAK-independent functions of ch-Tog/XMAP215 in microtubule plus-end dynamics. Barr AR, Gergely F. Mol Cell Biol. 2008 Dec;28(23):7199-211. doi: 10.1128/MCB.01040-08.
2007
Review: Aurora-A: the maker and breaker of spindle poles. Barr AR, Gergely F. J Cell Sci. 2007 Sep 1;120(Pt 17):2987-96.